In an interview with NPR, musician/singer Paul Simon was asked about the great mysteries of life:

We don't have the capacity to understand the great mysteries of life and God or no God or infinity, we just can't get it. It's beyond us, but that's fine. We're not meant to get that. But the pursuit is so interesting. That, I think, is life sustaining and I think when you lose the interest in that pursuit you're finished.

Source:

Bob Boilen; “Paul Simon says ‘I’m finished’ writing music”; NPR September 5, 2018